Juliet Claire Beavis;Judith Greenwood;Michael James Darsley;Jonathan Clive Stephens;Arthur Keith Turner
发明人:
Arthur Keith Turner,Judith Greenwood,Jonathan Clive Stephens,Juliet Claire Beavis,Michael James Darsley
申请号：
US13073999
公开号：
US08318148B2
申请日:
2011.03.28
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The invention provides strains of bacteria, especially enterotoxigenic E. coli, attenuated by mutations in the genes encoding enterotoxins (LT, ST, EAST1) and optionally further attenuated by deletion of additional chromosomal genes. In addition the invention provides strains of attenuated bacteria expressing immunogenic but non-toxic variants of one or more of these enterotoxins. These bacteria are useful as a vaccine against diarrhoeal disease.
