Disclosed are a trimetazidine sustained-release tablet and a preparation method therefor. The sustained-release tablet comprises a coating material for tablet film coatings and a tablet core coated by the coating material. The tablet core comprises pellets and excipients. The pellets successively comprise, from inside to outside, a drug-loading coating layer, a sustained-release coating layer and a protective coating layer. The drug-loading coating layer comprises trimetazidine and an adhesive for drug-loading pellet coatings. The sustained-release coating layer comprises a coating material for sustained-release pellet coatings, a pore-forming agent, a plasticizer and an anti-adhesion agent. The protective coating layer comprises a coating material for protective pellet coatings and a plasticizer for protective pellet coatings. The excipients comprise a filler, a disintegrating agent and a lubricant. The sustained-release tablet is coated with a protective layer outside of the sustained-release layer, thereby solving the problems, which easily occur during the process of tableting the pellets, such as decreased sustained release ability caused by the destruction of the sustained-release layer, and content uniformity not qualifying as a result of excessive fluidity, and also solving the problem of the burst release of the readily-soluble drug, trimethazine, in water.La présente invention concerne un comprimé de trimétazidine à libération prolongée et un procédé de préparation associé. Le comprimé à libération prolongée comprend un matériau de revêtement pour des revêtements en film de comprimé et un noyau de comprimé revêtu par le matériau de revêtement. Le noyau de comprimé comprend des pastilles et des excipients. Les pastilles comprennent successivement, de l'intérieur vers l'extérieur, une couche de revêtement à charge de médicament, une couche de revêtement à libération prolongée et une couche de revêtement de protection. La couche de revêtement à charge de médi
