THROMBIN MUTANT, POLYNUCLEOTIDE, RECOMBINANT VECTOR, TRANSFORMER, METHOD FOR PRODUCING A THROMBIN MUTANT, AND PHARMACEUTICAL COMPOSITION.

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专利权人:

CHISSO CORPORATION;FUJIMORI KOGYO CO., LTD.

发明人:

KAZUYA HOSOKAWA,TOMOKO WADA

申请号：

BRPI0718633

公开号：

BRPI0718633A2

申请日:

2007.11.15

申请国别(地区):

BR

年份:

2013

代理人:

摘要：

A thrombin mutant in which at least serine at position 205 among amino acids in the active center of the thrombin B chain has been replaced with another amino acid, and further at least one of the following replacements have been introduced: (I) replacement of arginine at position 89 in the B-chain with another amino acid； (II) replacement of threonine at position 69 or serine at position 22 in the B-chain with another amino acid； (III) replacement of alanine at position 200 in the B-chain with another amino acid； and (IV) replacement of lysine at position 65 in the B-chain with threonine.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/