PROBLEM TO BE SOLVED: To provide a tripeptide compound useful as a component of medicines or foods.SOLUTION: The present invention provides a tripeptide compound represented by one of the following formulas (1)-(5): Ace-Gly-Gln-Pro-COOR (1) Ace-Gln-Pro-Gly-COOR (2) Ace-Pro-Gly-Gln-COOR (3) Ace-Gly-Pro-Gln-COOR (4) and Ace-Gln-Gly-Pro-COOR (5), or a salt thereof. The tripeptide compound or a salt thereof has insulin secretion promoting action, GLP-1 secretion promoting action and blood glucose level reducing action, and can be used for a medicine or a food, such as a diabetes preventive or therapeutic agent.SELECTED DRAWING: Figure 3COPYRIGHT: (C)2016,JPO&INPIT【課題】医薬、食品の成分として有用なトリペプチド化合物を提供することを課題とする。【解決手段】下記(1)~(5)のいずれかの式で表されるトリペプチド化合物またはそれらの塩を提供する。それらトリペプチド化合物またはそれらの塩は、インスリン分泌促進作用、GLP-1分泌促進作用及び血糖値低減作用を有し、糖尿病予防剤または治療剤等の医薬または食品として使用可能である。Ace-Gly-Gln-Pro-COOR・・・(1)Ace-Gln-Pro-Gly-COOR・・・(2)Ace-Pro-Gly-Gln-COOR・・・(3)Ace-Gly-Pro-Gln-COOR・・・(4)Ace-Gln-Gly-Pro-COOR・・・(5)【選択図】図3
