<;P>;PROBLEM TO BE SOLVED: To provide a prevention, improvement and therapeutic agent of a metabolic disorder disease which occurs with age, and/or a drink and food having prevention, improvement and therapeutic action of the metabolic disorder disease which occurs with age. <;P>;SOLUTION: The prevention, improvement and therapeutic agent of the metabolic disorder disease containing a culture obtained by cultivating lactobacillus belonging to Bifidobacterium longum and/or a bacterial cell as an active ingredient, and further the drink and food having the prevention, improvement and therapeutic action of the metabolic disorder disease containing these active ingredients are prepared. <;P>;COPYRIGHT: (C)2010,JPO&INPIT