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TARGETING CORROLES FOR TUMOR TOXICITY AND MRI
专利权人:
Cedars-Sinai Medical Center
发明人:
Medina-Kauwe, Lali K.
申请号:
AU20180250401
公开号:
AU2018250401(A1)
申请日:
2018.10.17
申请国别(地区):
澳大利亚
年份:
2018
代理人:
摘要:
Docket No.: EOS.004US PATENT Disclosed herein are compositions comprising a targeted corrole nanoparticle; and an acceptable excipient. Also disclosed are compositions comprising a targeted corrole nanoparticle; and an acceptable carrier. Further, disclosed herein are methods of imaging a condition in a subject, comprising providing a composition comprising a targeted corrole nanoparticle; administering an effective amount of the targeted corrole nanoparticle to the subject; and imaging the condition in the subject. In addition, disclosed herein are methods of treating cancer in a subject, comprising providing a composition comprising a targeted corrole nanoparticle; and administering a therapeutically effective dosage of the targeted corrole nanoparticle to the subject. - 16 - Figure 2. r __ __ __ __Ar' Ar + Ar HerMn HO3s HerPBK10 SO3 H S2Mn Figure 2. Assembly of HerMn. Figure 3. A a 5 -.- HerMn B C 4 HerPBKIO 3- Saline ~E 3 z 0 0 z n 0 5 10 15 20 25 Saline HerMn Time (days after treatment) Da 30
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