THE INVENTION RELATES TO NEW THERAPEUTIC APPROACHES FOR TREATING CANCER, IN PARTICULAR HEPATOCELLULAR CARCINOMA, WITH NANOPARTICULES LOADED WITH A CHEMOTHERAPEUTIC ANTITUMORAL AGENT. IN PARTICULAR, IT RELATES TO THE TREATMENT OF CANCER BY ADMINISTRATION OF SAID NANOPARTICULES BY INTRAVENOUS INFUSION FOR AT LEAST 2 HOURS IN ORDER TO PREVENT TOXICOLOGICAL SIDE EFFECTS AND INCREASE THE BENEFIT/RISK RATIO OF THE TREATMENT. (NO SUITABLE FIGURE)