Purinylpyridinylamino-2,4-difluorophenylsulfonamide derivative, pharmaceutically acceptable salt thereof, method of preparation thereof and pharmaceutical composition with inhibitory activity against Raf kinase, which contains the same as active ingredient
SHIM, Eun Kyong,KIM, Nam Doo,SHIM, Tae Bo,KIM, Seung Yong
申请号：
ES11844745
公开号：
ES2562010T3
申请日:
2011.11.25
申请国别(地区):
ES
年份:
2016
代理人:
摘要：
A new derivative of purinylpyridinylamino-2,4-difluorophenylsulfonamide represented by the following Formula 1 or a pharmaceutically acceptable salt thereof: ** Formula ** (In Formula 1 above, R is linear or branched C1-C6 alkyl； C3 cycloalkyl； C6 not substitutable or substituted with one or more selected from the group consisting of halogen and C1-C6 straight or branched alkyl； C5-C6 aryl substituted with one or more selected from the group consisting of halogen, C1-C6 straight or branched alkyl, and C1-C6 linear or branched alkoxy substituted with C1-C6 linear or branched alkoxy and halogen； C5-C12 single or double ring heteroaryl not substitutable or substituted with one or more selected from the group consisting of C1-C6 linear or branched alkyl substituted with halogen, linear or branched C1-C6 alkyl, linear or branched C1-C6 alkyloxycarbonyl, and C5-C6 heterocycloalkyl containing one or more oxygen (O) in the ring； non-substitutable C5-C6 heterocycloalkyl or substituted with one or more selected from the group consisting of halogen and C1-C6 linear or branched alkyl； or aryl (C5-C6) -alkyl (linear or branched C1-C6) not substitutable or substituted with halogen, nitro and linear or branched C1-C6 alkyl； this time, the heteroaryl and the heterocycloalkyl contain one or more heteroatoms selected from the group consisting of N, O and S in the ring.)Un nuevo derivado de purinilpiridinilamino-2,4-difluorofenilsulfonamida representado por la Fórmula 1 posterior o una sal farmacéuticamente aceptable del mismo:**Fórmula** (En la Fórmula 1 anterior, R es alquilo lineal o ramificado C1-C6； cicloalquilo C3-C6 no sustituible o sustituido con uno o más seleccionados del grupo que consiste en halógeno y alquilo lineal o ramificado C1-C6； arilo C5-C6 sustituido con uno o más seleccionados del grupo que consiste en halógeno, alquilo lineal o ramificado C1-C6, y alcoxi lineal o ramificado C1- C6 sustituido con alcoxi lineal o ramificado C1-C6 y halógeno； heteroarilo de anillo
