ВАН ДЕН БУССЕ Хелена (SE),ПОЛЬСОН Кристиан (SE),БОРГСТРЁМ Юхан (SE),СВЕНСОН Биргитта (SE),ХОЛЬМБЕРГ Анна (SE),ЛИНДАЛЬ Оке (SE),ТЕЛИН Бернт (SE)
申请号：
RU2011111206/15
公开号：
RU2011111206A
申请日:
2009.10.29
申请国别(地区):
RU
年份:
2012
代理人:
摘要：
1. A topical composition containing a lipophilic drug, a combination of at least two penetration enhancing agents, wherein at least one of the penetration enhancing agents is selected from the group consisting of saturated or unsaturated fatty acid esters and lower alcohols and isoforms alcohols； wherein at least one of the penetration enhancing agents is selected from the group consisting of aliphatic diols and triols； moreover, the drug is selected from the group consisting of immunomodulators or modifiers of the immune response, tricyclic antidepressants, analgesics, anesthetics, anti-inflammatory drugs, β-blockers, antimicrobial agents and agents that block Ca； and wherein said components are present in a non-aqueous solvent system. 2. The composition of claim 1, wherein the medicament comprises an immunomodulatory compound. The composition of claim 2, wherein the immunomodulatory compound comprises a toll-like receptor ligand 7 (TLR7). The composition according to claim 2, characterized in that the immunomodulatory compound is imiquimod. The composition according to claim 1, characterized in that the drug is contained in the composition in an amount of from about 0.01 to about 5% of the total weight of the composition. The composition according to claim 1, characterized in that the alcohol is isopropyl alcohol or isobutyl alcohol. The composition of claim 1, wherein the penetration enhancing agents include isopropyl myristate and propylene glycol. The composition according to claim 1, characterized in that the total number of penetration enhancing agents1. Композиция для местного применения, содержащая липофильное лекарственное средство, комбинацию по меньшей мере двух агентов, усиливающих проникновение, при этомпо меньшей мере один из агентов, усиливающих проникновение, выбран из группы, состоящей из эфиров насыщенных или ненасыщенных жирных кислот и низших спиртов и изоформ спиртов； при этомпо меньшей мере один из агентов, усиливающих проникновение, выбран из
