Also disclosed herein are pharmaceutical compositions comprising an antibody or antigen-binding fragment thereof that binds SSEA-4, as well as methods of use thereof. Methods of use include, but are not limited to, cancer treatment and diagnostic methods. The antibodies of the present disclosure can bind to the surface of certain cancer cells. Exemplary targets of the antibodies disclosed herein include brain tumor, lung cancer, breast cancer, oral cancer, esophageal cancer, stomach cancer, liver cancer, bile duct cancer, pancreatic cancer, colon cancer, kidney cancer , Cervical cancer, ovarian cancer, and / or carcinoma within prostate cancer.本明細書では、ＳＳＥＡ－４に結合する抗体またはその抗原結合性断片を含む医薬組成物、ならびにその使用方法も開示される。使用方法は、限定せずに述べると、がんの治療および診断法を含む。本開示の抗体は、ある特定のがん細胞表面に結合しうる。本明細書で開示される抗体の例示的な標的は、脳腫瘍、肺がん、乳がん、口腔がん、食道がん、胃がん、肝臓がん、胆管がん、膵臓がん、結腸がん、腎臓がん、子宮頚がん、卵巣がん、および／または前立腺がん内の癌腫などの癌腫を含みうる。
