MACDONALD LYNN,GURER CAGAN,MURPHY ANDREW J.,TU NAXIN,VORONINA VERA,STEVENS SEAN
申请号：
NZ62314612
公开号：
NZ623146A
申请日:
2012.10.26
申请国别(地区):
NZ
年份:
2016
代理人:
摘要：
Disclosed is a non-human animal comprising at an endogenous Major Histocompatibility Complex II (MHC II) &alpha； gene locus a nucleotide sequence encoding a chimeric human/non-human MHC II &alpha； polypeptide and/or comprising at an endogenous MHC II &bgr； gene locus a nucleotide sequence encoding a chimeric human/non-human MHC II &bgr； polypeptide, wherein a human portion of the chimeric human/non-human MHC II &alpha； polypeptide comprises a human MHC II &alpha；2 extracellular domain, and/or a human portion of the chimeric human/non-human MHC II &bgr； polypeptide comprises human MHC II &bgr；2 domains, and wherein the animal expresses a functional MHC II complex on a surface of a cell of the animal.
