The present invention relates to new derivatives of heterocyclic prolinamide of formula I and their pharmaceutically acceptable salts, solvates, salt solvates and prodrugs useful for prevention (for example, delaying the onset or reducing the risk of development) and treatment (for example, controlling, alleviating or slowing the progression of age-related macular degeneration ( AMD) and related eye diseases). These diseases include dry AMD, wet AMD, geographic atrophy, diabetic retinopathy, preterm retinopathy, polyphoid choroidal vasculopathy, and retinal or photoreceptor cell degeneration. The invention disclosed in the present disclosure further relates to methods of preventing, slowing down the development and treatment of dry AMD, moist AMD, geographical atrophy, diabetic retinopathy, preterm retinopathy, polyporous choroidal vasculopathy, and degeneration of retinal or photoreceptor cells, including the administration of a therapeutically effective amount of a compound of the invention . The compounds of the invention are inhibitors of HTRA1. Thus, the compounds of the invention are useful for the prevention and treatment of a wide range of diseases mediated (fully or partially) by HTRA1. The compounds of the invention are also useful for inhibiting the activity of the HTRA1 protease at the eye or locus of an arthritis or related condition.Настоящее изобретение относится к новым производным гетероциклического пролинамида формулы Iи их фармацевтически приемлемым солям, сольватам, сольватам соли и пролекарствам, полезным для профилактики (например, замедления наступления или снижения риска развития) и лечения (например, контроля, облегчения или замедления прогрессирования возрастной макулярной дегенерации (AMD) и связанных с ней заболеваний глаз). Эти заболевания включают сухую AMD, влажную AMD, географическую атрофию, диабетическую ретинопатию, ретинопатию недоношенных, полипообразную хориоидальную васкулопатию и дегенерацию ретинальных или фоторецепторных кле
