Universite d'Evry Val d'Essonne;Institut National de la Santé et de la Recherche Médicale;Association Francaise Contre Les Myopathies
发明人:
PESCHANSKI, Marc,BLONDEL, Sophie,NISSAN, Xavier
申请号：
ES15775223
公开号：
ES2751623T3
申请日:
2015.10.07
申请国别(地区):
ES
年份:
2020
代理人:
摘要：
A compound or any of its pharmaceutically acceptable salts, in the form of enantiomers, diastereoisomers and their mixtures, including the racemic mixture, for use in the treatment and / or prevention of diseases or disorders in which an inhibition of protein prenylation, where the diseases or disorders are selected from a progenic disease, a neurodegenerative disease, a metabolic disease； a mitochondrial disease, an eye disease, an inflammatory disease, a cardiovascular disease, a proliferative disease, an immune disease, cerebral infarction, skin aging, hormonal aging and viral infection, which is alternatively chosen from ** Formula ** where R1 is 2-pyridyl, 3-pyridyl, or 4-pyridyl； R2 represents a group selected from the group consisting of: ** Formula ** where R3 represents a group selected from the group consisting of: - an arylcarbonyl group, - a heteroarylcarbonyl group, - a (C1-C4) alkoxy group -carbonylmethyl and ** Formula ** - a group, being Ra, Rb, Rc, Rd and Re, independently, a hydrogen atom, a halogen atom, a (C1-C4) alkyl group or a (C1-) alkoxy group C4), optionally together forming Ra and Rb, or Rb and Rc, or Rc and Rd, or Rd and Re with the carbon atom to which a fused 5 or 6-membered ring is attached to the phenyl ring comprising two oxygen atoms , and R4 being a phenyl group substituted with a halogen atom, or a benzyl group； with the proviso that R3 is not a 4-methylbenzyl group when R1 is 2-pyridyl, and ** Formula ** wherein R5 represents a hydrogen atom or a (C1-4) alkyl group； R6 represents a hydrogen atom or a (C1-4) alkyl group； and R7 represents a group selected from the group consisting of: - an arylcarbonyl group, - a heteroarylcarbonyl group optionally substituted with one or two groups selected from a (1-4C) alkyl group and a phenyl group, - an optionally heteroarylacetyl group substituted on the heteroaryl ring with a phenyl group, - a (C1-C4) alkoxy -carbonylmethyl group and ** Formula ** - a group, Ra, Rb, Rc, Rd and Re, independe
