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5-Phenyl-pyrazolopyridine derivatives, their preparation and their application in therapeutics
专利权人:
SANOFI
发明人:
AUGER, FLORIAN,DE PERETTI, DANIELLE,EVEN, LUC
申请号:
ES10771159
公开号:
ES2523505T3
申请日:
2010.09.17
申请国别(地区):
ES
年份:
2014
代理人:
摘要:
Compounds of formula (I): in which: R 1 represents: a phenyl group or a naphthyl group, these two groups being optionally substituted with one or more atoms or groups independently selected from each other among the following atoms or groups: halogen, (C1-C6) alkyl, halo (C1-C6) alkyl, (C1-C6) alkoxy, halo (C1-C6) alkoxy, (C1-C6) thioalkyl, -S (O) (C1-C6) alkyl , -S (O) 2 (C1-C6 alkyl), hydroxyl, hydroxy-C1-C6 alkylene, CHO, COOH, (C1-C6) alkoxy (C1-C6) alkylene -oxy, NRaRb, CONRaRb, SO2NRaRb, NRcCORd, OC (O) NRaRb, OCO-C1-C6 alkyl, NRcC (O) ORe, NRcSO2Re, X represents 1 to 4 identical or different substituents from each other, chosen from hydrogen, halogen, C1-C6 alkyl ), (C1-C6) alkoxy, the (C1-C6) alkyl may be optionally substituted with one or more groups selected from a halogen, (C1-C6) alkoxy, hydroxyl, R2 and R3 independently represent one another. hydrogen atom, a (C1-C6) alkyl group optionally substituted with a group Rf; a CHO, COOH, X and R3 group can form together with the carbon atoms that carry them, a carbon cycle of 5 to 7 carbon atoms; R4 represents a hydrogen atom or a (C1-C6) alkyl group, Ra and Rb represent, independently of one another, a hydrogen atom or a (C1-C6) alkyl, aryl (C1-C6) arylalkylene or aryl group; or Ra and Rb together with the nitrogen atom carried by an azetidino, pyrrolidino, piperidino, azepino, morpholino, thiomorpholino, piperazino, homopiperazino group, this group being optionally substituted with a (C1-C6) alkyl, aryl or aryl group -C1-C6 alkylene; Rc and Rd represent, independently of one another, a hydrogen atom or a (C1-C6) alkyl, arylalkylene (C1-C6), aryl group; or Rc and Rd together form an alkylene group (C2-C5); Re represents a (C1-C6) alkyl, aryl (C1-C6) alkylene, aryl group; or Rc and Re together form an alkylene group (C2-C5); Rf represents a hydroxyl group, an oxo, CHO or COOH group, in the form of a base or an acid addition salt.Compuestos de fórmula (I): en la que: R1 representa: un grupo fenilo o un grupo na
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