A portable imaging system for imaging a region of interest (ROI) includes a housing (12), a radiation detector(16)mounted to the housing (12), the detector generating radiation data indicating a location of gamma photon strikes on the detector, a motion sensor (20) which senses motion of the detector and outputs motion data indicative of the location and orientation of the detector at the time of each gamma photon strike, and at least one processor (22, 26) programmed to receive the radiation data from the radiation detectors (16) and the motion data from the motion sensor (20) and reconstruct a 3D volume image of the ROI from the received radiation and motion data.
