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PRÉPARATION D'IRINOTÉCAN
专利权人:
KABUSHIKI KAISHA YAKULT HONSHA
发明人:
申请号:
EP05745848.1
公开号:
EP1752150B1
申请日:
2005.05.31
申请国别(地区):
EP
年份:
2016
代理人:
摘要:
Provided is an irinotecan formulation capable of supporting irinotecan and/or a salt thereof in a closed vesicle carrier at a high concentration and existing in blood for a long period of time by dramatically improved retentivity in blood compared to a conventionally known irinotecan liposome formulation. That is, an irinotecan formulation including a closed vesicle formed by a lipid membrane, in which irinotecan and/or a salt thereof is encapsulated at a concentration of at least 0.07 mol/mol (drug mol/membrane total lipid mol). There is an ion gradient between an inner aqueous phase and an outer aqueous phase in the irinotecan formulation. The closed vesicle is preferably liposome, in which only the outer surface of the liposome is preferably modified with a surface-modifying agent containing a hydrophilic polymer.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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