Gerardo M. Castillo,Akiko Nishimoto-Ashfield,Elijah M. Bolotin
申请号：
US16577947
公开号：
US20200017567A1
申请日:
2019.09.20
申请国别(地区):
US
年份:
2020
代理人:
摘要：
This disclosure provides a natriuretic peptide derivative of Formula (I), and to compositions including a natriuretic peptide derivative of Formula (I),(fatty acyl)z-(B)x-(G)y-NP ； ； (I),wherein: z is 1, x is an integer from 2 to 4 and y is 3； or z is 0, x is an integer from 0 to 4 and y is an integer from 1 to 3； fatty acyl comprises from 12 to 24 (e.g., 12 to 18) carbons atoms； B is lysine or arginine； G is glycine； NP is a natriuretic peptide； if present, (fatty acyl)z- is covalently linked to the N-terminus of (B)x； (fatty acyl)z-(B)x- is covalently linked to the N-terminus of (G)y； and (fatty acyl)z-(B)x-(G)y- is covalently linked to the N-terminus of NP. The natriuretic peptide derivative according to the disclosure, and compositions thereof, are useful in the treatment of diseases such as hypertension, vascular congestion, and heart disease.
