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Inhibitors of serine / Threonine Kinase
专利权人:
ARRAY BIOPHARMA, INC.;GENENTECH, INC.
发明人:
PETER J. MOHR,KIRK ROBARGE,JACOB SCHWARZ,AIHE ZHOU,SAM KINTZ,JAMES F. BLAKE,LEWIS GAZZARD,HUIFEN CHEN,MARK JOSEPH CHICARELLI,JOHN GAUDINO
申请号:
ARP130103040
公开号:
AR092253A1
申请日:
2013.08.27
申请国别(地区):
AR
年份:
2015
代理人:
摘要:
Describes compositions and Methods for treating Disorders hiperproliferativos.Claim 1: a compound according to formula (1): where X is CH or N; Z is (i) NH (ch u2082) u2099chr u00b9ar where n is 0 OR 1, or (ii) 1 - alkyl - 4 - aryl - pyrrolidin-3-yl ilamina - 3 - or 4 - aryl - pyrrolidin-3-yl - 3 - ilamina where alkyl is optionally substituted with a c u2081 u208b u2083 alkyl and aryl phenyl ring is f Enilo optionally substituted; r u00b9 is Hydrogen, (TO)(b) c u2081 u208b u2086 alkyl, optionally substituted with one or more hydroxyl or alkoxy groups c u2081 u208b u2086, (c) alquenilo c u2081 u208b u2086 optionally substituted with one or more hydroxyl or alkoxy groups c u2081 u208b u2086, (d) alquinilo c u2081 u208b u2086 with one or more hydroxyl or alkoxy groups c u2081 u208b u2086 cycloalkyl, (e) C u2083 u208b u2086 optionally substituted with one or More groups that are selected from the group consisting c u2081 u208b u2086 Hydroxy, alkoxy,C u2081 u208b u2086 alkyl and Halogen; (f) a heterocycle of 4 to 6 members with one or two heteroatoms are selected from N or o, where the heterocycle is optionally substituted with one or More groups that are selected from the group consisting c u2081 u208b u2086 hydroxyl alkyl, alkoxy, and Hal c u2081 u208b u2086 u00f3geno a heteroaryl, or (g) of 5 to 6 members, with one or two heteroatoms are selected from N or o,Where is optionally substituted heteroaryl groups with one or more selected from the group consisting c u2081 u208b u2086 hydroxyl alkyl, alkoxy, halogen and c u2081 u208b u2086; ar is phenyl or indolilo pyridinyl optionally replaced with 1 to 3 groups regardless of (Selected) Rent c u2081 u208b u2086 haloalquilo c u2081 u208b u2086, (b), (c), (d) c u2081 u208b u2086 alkoxy, halogen c u2083 u208b u2086 cycloalkyl, (e), (f) haloalcoxi c u2081 u208b u2086,(g) Alquiltio c u2081 u208b u2086 Ciano, (f), (g), (H) phenoxy benzyl, which are optionally substituted phenoxy benzyl with Halogen, alkyl or alkoxy c u2081 u208
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