Human leucine zipper/trail recombinant polypeptides

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专利权人:

发明人:

Dmitri Rozanov,Alexander Aleshin

申请号：

US15081300

公开号：

US10131701B2

申请日:

2016.03.25

申请国别(地区):

US

年份:

2018

代理人:

摘要：

Disclosed are recombinant polypeptides that include human TRAIL sequences as well as human leucine zipper motifs as well as polynucleotides that encode the recombinant polypeptides, expression vectors that comprise the polynucleotides, pharmaceutical compositions comprising the polypeptides, and methods of using the pharmaceutical compositions for the treatment of cancer. Further disclosed are TRAIL sequences with stabilizing mutations and methods of expressing the disclosed polypeptides in E. coli.

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