compound, pharmaceutical composition and abstract method the present invention relates to a transcription factor eb (tfeb) protein, ortholog, recombinant or synthetic or biotechnological functional derivative thereof, allelic variant thereof and fragments thereof； a chimeric molecule comprising the teb protein, ortholog, recombinant or synthetic or biotechnological functional derivative thereof, allelic variant thereof and fragments thereof； a polynucleotide coding for said protein or ortholog, recombinant or synthetic or biotechnological functional derivative thereof, allelic variant thereof and fragments thereof； the comprising said polynucleotide vector； a host cell genetically engineered expressing said polypeptide or a pharmaceutical composition for use in the treatment or prevention of a glycogen storage disease. preferably of pompe or danon disease.composto, composição farmacêutica e método abstract the present invention relates to a transcription factor eb (tfeb) protein, ortholog, recombinant or synthetic or biotechnological functional derivative thereof, allelic variant thereof and fragments thereof； a chimeric molecule comprising the tfeb protein, ortholog, recombinant or synthetic or biotechnological functional derivative thereof, allelic variant thereof and fragments thereof； a polynucleotide coding for said protein or ortholog, recombinant or synthetic or biotechnological functional derivative thereof, allelic variant thereof and fragments thereof； a vector comprising said polynucleotide； a host cell genetically engineered expressing said polypeptide or a pharmaceutical composition for use in the treatment or/and prevention of a glycogen storage disease. preferably of pompe or danon disease.
