CHRISTOPH WOLFGANG ZAPF,STEPHEN WAYNE WRIGHT,JOHN DAVID TRZUPEK,JOSEPH WALTER STROHBACH,EDDINE SAIAH,NIKOLAOS PAPAIOANNOU,JOHN PAUL MATHIAS,FRANK ELDRIDGE LOVERING,ARTHUR LEE,DAVID HEPWORTH,SEUNGIL HA
申请号：
ARP160102625
公开号：
AR105845A1
申请日:
2016.08.26
申请国别(地区):
AR
年份:
2017
代理人:
摘要：
And also Pharmaceutical compositions for use in treatment of inflammatory diseases.Claim 1: a compound characterized by the formula (1), wherein X, X ', and' are each independently, or CH N； Z is c or N； provided that no more than three Z, X, X ', and' n； r u00b9 is c u2081 u208b u2086alquilo o - (c u2081 u208b u2086alquil) u2099 (c u2081 u208b u2086cicloalquilo), where the alkyd ILO or cycloalkyl optionally replaced with deuterium, halogen, NS,Oh, or c u2081 u208b u2086alcoxi； R u00b2 is Hydrogen or Methyl； r u00b3 is Hydrogen, deuterium, halogen, nitryl, - (ch u2082) u209cnr u2078 u1d43r u2078 u1d47, (ch u2082 u209c (aryl) - 6 - (10 members) or ch u2082 u209c (heteroaryl) from 5 to 10 members), which has 1 to 3 heteroatoms selected N or, or, where the seed heter Oarilo optionally substituted with 1 to 3 c u2081 u208b u2086alquilo, deuterium, halogen, CN, oHydroxy c u2081 u208b u2086alquilo or c u2081 u208b u2086alcoxi； where replaced optionally with hydroxyl alkyl, halogen, cn or c u2081 u208b u2083alcoxi； r u2074 u1d43 and r u2074 u1d47 are each independently Hydrogen, Fluorine, Oh, c u2081 u208b u2083alcoxi or ch u2082or u2077, where r u2077, along with r u00b9 is a c u2081 u208b u2084alqu Full, optionally substituted alkyl or Halogen； r u2075 u1d43 and r u2075 u1d47 are each independently, or Hydrogen, c u2081 u208b u2083alquilo c u2081 u208b u2083alcoxi,Where the alkyl or alkoxy optionally 1 to 3 are replaced with deuterium, halogen, or Oh and CN； or r u2075 u1d43 r u2075 u1d47, together with the Atom to which they are United, form a c u2083 u208b u2087cicloalquilo or c u2083 u208b u2087heterocicloalquilo, where heterocicloalquilo cycloalkyl or optionally substituted With 1 to 3 deuterium, halogen, Oh, cn or c u2081 u208b u2083alquilo； r u2076 is Hydrogen or c u2081 u208b u2083alquilo r u2075 u1d47 and r u2076； or,Together with the Atom to which they are United, form a c u2083 u208b u2087cicloalquilo or c u2083 u208b u2087heterocicloalquilo, where heteroci
