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METHODS OF MAKING AND USING A CELL PENETRATING PEPTIDE FOR ENHANCED DELIVERY OF NUCLEIC ACIDS, PROTEINS, DRUGS, AND ADENOVIRUS TO TISSUES AND CELLS, AND COMPOSITIONS AND KITS
专利权人:
TUFTS UNIVERSITY
发明人:
KUMAR-SINGH, RAJENDRA,CASHMAN, SIOBHAN, M.
申请号:
EP08795653
公开号:
EP2195001A4
申请日:
2008.08.28
申请国别(地区):
EP
年份:
2012
代理人:
摘要:
A peptide-POD with ability to penetrate and deliver fluorophores, siRNA, DNA and quantum dots to cells in culture and retinal and ocular tissues in vivo is provided herein. POD couples to adenovirus vectors, enhancing tropism for certain cells, potentially providing a safer and more efficacious method to deliver molecules to ocular and other tissues in vivo. POD constructs are therapeutic delivery vehicles for treating cells and tissues, including ocular cells and tissues suffering from retinal degeneration.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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