COMPOSÉS DE DIOXANE-QUINAZOLINE ET DE DIOXANE-QUINOLÉINE LIÉS À UN CYCLE AROMATIQUE SUBSTITUÉS PAR DE L'URÉE, LEUR PROCÉDÉ DE PRÉPARATION ET LEUR UTILISATION

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专利权人:

Beijing Scitech-MQ Pharmaceuticals Limited

发明人:

ZHANG, Qiang,ZHANG, Hongbo,YANG, Leifu,YANG, Hailong,ZHOU, Likai,ZHENG, Nanqiao,YU, Shannan,WANG, Zhongxiang,FENG, Shouye,XU, Zhanqiang

申请号：

EP18761220

公开号：

EP3590941A4

申请日:

2018.02.11

申请国别(地区):

EP

年份:

2020

代理人:

摘要：

The present invention relates to a urea-substituted aromatic ring-linked dioxane-quinazoline compound of Formula (I) and a urea-substituted aromatic ring-linked dioxane-quinoline, or a pharmaceutically acceptable salt thereof or a hydrate thereof. Also provided are the preparation of the compound as shown in Formula (I) and the pharmaceutically acceptable salt thereof and the use thereof as a drug. The drug is used as an inhibitor of tyrosine kinases (e.g., VEGFR-2, C-RAF, B-RAF) for treating tyrosine kinase-related diseases.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/