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drug-containing cell vehicle for formation of an immune complex
专利权人:
CHUGAI SEIYAKU KABUSHIKI KAISHA
发明人:
NAOKA HIRONIWA,TOMOYUKI IGAWA
申请号:
BR112014013081
公开号:
BR112014013081A2
申请日:
2012.11.30
申请国别(地区):
BR
年份:
2017
代理人:
摘要:
abstract the present inventors discovered that by forming a large immune complex comprising antigens containing two or more antigenic binding units (epitopes) and two or more antigen-binding molecules (for example, antibodies), elimination from the plasma of the antigens containing two or more antigenic binding units can be accelerated. moreover, they found that by using this characteristic and by further using antigen-binding molecules having an ion-dependent antigen-binding activity, elimination of the antigens can be further accelerated and the above problem can be solved. -------------------------------------------------- -------------------------------------------------- ------- translation of the patent abstract: "drug-containing cell vehicle for formation of an immune complex". The present inventors have found that by forming a larger immune complex comprising antigens containing two or more antigen-binding units (epitopes) and two or more antigen-binding molecules (e.g., antibodies), the elimination from the plasma of antigens containing two or more antigen binding units can be accelerated. In addition, they found that by the use of this feature and by the additional use of antigen binding molecules having an ion-dependent antigen binding activity, antigen clearance can still be accelerated. And the above problem can be solved.abstract the present inventors discovered that by forming a large immune complex comprising antigens containing two or more antigenic binding units (epitopes) and two or more antigen-binding molecules (for example, antibodies), elimination from the plasma of the antigens containing two or more antigenic binding units can be accelerated. moreover, they found that by using this characteristic and by further using antigen-binding molecules having an ion-dependent antigen-binding activity, elimination of the antigens can further be accelerated and the above problem can be solved. ------------------------------------------------------------
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