INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION
发明人:
DIMARCHI, RICHARD, D.,LI, PENGYUN
申请号：
EP12859172
公开号：
EP2793932A4
申请日:
2012.12.19
申请国别(地区):
EP
年份:
2015
代理人:
摘要：
Insulin analogs comprising a non-native glycosylation site sequence are provided having high potency and specificity for the insulin receptor. In one embodiment a peptide sequence of greater than 18 amino acids is used as a linking moiety to link human insulin A and B chains, or analogs or derivatives thereof, to provide high potency single chain insulin analogs. In one embodiment the linking moiety comprises one or more glycosylation sites. Also disclosed are prodrug and conjugate derivatives of the insulin analogs.
