Chelate of oligonucleotides oligonucleotides which comprises two or more linked by a multivalent cation where at least one of said oligonucleotide complex has at least one Link phosphorothioate； Pharmaceutical composition containing same and its uses.
The present disclosure describes the broadly active chelation of diverse divalent 2+ metal cations by any oligonucleotide (ON), regardless of size or modification. This chelation effect is specific to cations which are divalent (or of higher valency) and results in the formation of oligonucleotide chelate complexes which do not behave like salts. It is described herein a novel composition of an ON chelate complex prepared using any ON and a divalent metal cation and methods for the suppression of anti-coagulation and or subcutaneous injection site reactions and or improved tolerability with oligonucleotides by the use of ON chelate complexes during oligonucleotide administration.QUELATO DE OLIGONUCLEOTIDOS QUE COMPRENDE DOS O MAS OLIGONUCLEOTIDOS ENLAZADOS POR UN CATION MULTIVALENTE DONDE AL MENOS UN OLIGONUCLEOTIDO DE DICHO COMPLEJO TIENE AL MENOS UN ENLACE FOSFOROTIOATO； COMPOSICION FARMACEUTICA QUE LO COMPRENDE； Y SUS USOS.
