N - [4 - (quirolin-4-iloxi) cyclohexyl (methyl)] (heterogeneous) arilcarboxamidas as the opposite cube of androgenes receptor, its production and use as medicinal products
NGUYEN, DUY,KUNZER, HERMANN,FAUS GIMENEZ, HORTENSIA,BADER, BENJAMIN,KOHR, SILKE,FRITSCH, MARTIN
申请号：
PE2014002495
公开号：
PE20150154A1
申请日:
2013.06.24
申请国别(地区):
PE
年份:
2015
代理人:
摘要：
It refers to the compounds produced from n - [4 - (quinolin-4-iloxi) cyclohexil (methyl)] (heterogeneous) formula arilcarboxamidas (I), wherein R1, a and N are the compounds defined in the description. They are the preferred compounds: n - ({trans-4 - [(8-fluoroquinolin-4-il) ox] cyclohexyl} met) - 4-fluorobenzamida； N - {trans-4 - [(8-bromoquinlin-4-il) ox] cyclohexyl} - 5-methylisoxazol-3-carboxamida, etc. He also mentioned a preparatory process and a pharmaceutical composer. These compounds are antagonistic to androgenes receptors and are useful tools for the treatment of highly proliferative diseases.SE REFIERE A COMPUESTOS DERIVADOS DE N-[4-(QUINOLIN-4-ILOXI)CICLOHEXIL(METIL)](HETERO)ARILCARBOXAMIDAS DE FORMULA (I) DONDE R1, A Y n SON COMO SE DEFINEN EN LA DESCRIPCION. SON COMPUESTOS PREFERIDOS: N-({TRANS-4-[(8-FLUOROQUINOLIN-4-IL)OXI]CICLOHEXIL}METIL)-4-FLUOROBENZAMIDA； N-{TRANS-4-[(8-BROMOQUINOLIN-4-IL)OXI]CICLOHEXIL}-5-METILISOXAZOL-3-CARBOXAMIDA； ENTRE OTROS. TAMBIEN SE REFIERE A UN PROCEDIMIENTO DE PREPARACION Y A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON ANTAGONISTAS DEL RECEPTOR DE ANDROGENOS SIENDO UTILES EN EL TRATAMIENTO DE ENFERMEDADES HIPERPROLIFERATIVAS
