A high-intensity focused ultrasound handpiece (HIFU) device for skin care, includes a handpiece body including a high frequency generator and a controller, which are disposed in the handpiece body, a cartridge detachably coupled to the handpiece body, electrically connected to the handpiece body in a coupled state, and filled with a fluid for generation of ultrasound, the cartridge being provided with a contact head to come into close contact with a skin of a person to be treated, and a piezoelectric driving device dipped in the fluid in the cartridge and provided with a transducer for irradiating the skin with high-intensity focused ultrasound in accordance with a high frequency signal generated from the high frequency generator.
