The disclosure generally relates to compounds of formula I, including their salts, as well as compositions and methods of using the compounds. The compounds are ligands of the NR2B receptor and may be useful for the treatment of various disorders of the central nervous system.本發明概言之係關於式I化合物(包括其鹽)以及使用該等化合物之組合物及方法。該等化合物係NR2B受體之配體且可用於治療多種中樞神經系統病症。