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EPIDITHIODIOXOPIPRAZINES AND USES THEREOF IN TREATING CANCER
专利权人:
Feiyan Liu
发明人:
Feiyan Liu,Kebin Liu,Ping Wu
申请号:
US13404503
公开号:
US20120219568A1
申请日:
2012.02.24
申请国别(地区):
US
年份:
2012
代理人:
摘要:
Compositions containing epidithiodioxopiprazines and methods of their use are provided. Epidithiodioxopiprazines can be isolated from natural resources or synthesized de novo. Moreover, epidithiodioxopiprazines, including Verticillin A, are shown to effectively sensitize multiple types of tumor cells to TRAIL-induced apoptosis. In addition, epidithiodioxopiprazines, including Verticillin A, are shown to effectively overcome cancer cell resistance to existing drugs (i.e. Etoposide, Cisplatin, 5-FU and Doxorubicin). Therefore, compositions and methods are provided for use in sensitizing target cancer cells to death receptor- and other anticancer drugs-induced apoptosis. Methods of treating cancer in a subject in need thereof are also provided.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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