The invention provides a disposable endometrial biopsy device comprising an elongated blunt-end catheter with distally placed tissue acquisition side-hole and proximally attached aspiration syringe with spring-loaded plunger having latching mechanism to release plunger for induction of aspiration. The device has a pin-hole channel or filter acting as a tissue trap between the catheter channel and the syringe in order to prevent aspiration of tissue into the body of the syringe.