The Broad Institute, Inc.;Massachusetts Institute of Technology;President and Fellows of Harvard College
发明人:
Julia Joung,Jesse Engreitz,Eric S. Lander,Feng Zhang
申请号：
US16611025
公开号：
US20200248184A1
申请日:
2018.05.04
申请国别(地区):
US
年份:
2020
代理人:
摘要：
The application relates to methods for compositions for identifying IncRNA loci associated with target genotypes or phenotypes, including desirable plant genotypes or phenotype. The application also relates to regulatory regions and genes associated with drug resistance, such as resistance to BRAF-inhibitors. Such regulatory regions and genes form the basis for methods for identifying resistance to BRAF-inhibitors, which is useful for improving disease prognosis, treatment, and likely outcomes. The regulatory regions and genes are also suitable targets for therapy in melanoma that is resistant to BRAF-inhibitors.
