ASAKO NAGATA,CYNTHIA PALMER LOUISE,DOUGLAS CARL BEHENNA,EUGENE YUANJIN RUI,KEVIN DANIEL FREEMAN-COOK,MARTHA ALICIA ORNELAS,MEHRAN JALAIE,PING CHEN,ROBERT LOUIS HOFFMAN,SACHA NINKOVIC,SAJIV KRISHNAN NA
申请号：
BR112019002610
公开号：
BR112019002610A2
申请日:
2017.07.31
申请国别(地区):
BR
年份:
2019
代理人:
摘要：
this invention relates to compounds of formula (i) (i), and pharmaceutically acceptable salts thereof, wherein r1, r2, r2a, r2b, r3, r4, r5a, r5b, r6, r7, r8, r9, e.g., as defined herein, to pharmaceutical compositions comprising such compounds and salts, and methods of using such compounds, salts and compositions for the treatment of abnormal cell growth, including cancer.esta invenção refere-se a compostos de fórmula geral (i) (i), e sais farmaceuticamente aceitáveis dos mesmos, em que r1, r2, r2a, r2b, r3, r4, r5a, r5b, r6, r7, r8, r9, p, q e r são como definidos aqui, às composições farmacêuticas compreendendo tais compostos e sais, e aos métodos de usar tais compostos, sais e composições para o tratamento do crescimento celular anormal, incluindo câncer.
