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Crystalline derivatives of 3,3-diphenylpropylamines and process for preparing thereof
专利权人:
Schwarz Pharma AG
发明人:
Meese, Claus
申请号:
NO20065380
公开号:
NO332637B1
申请日:
2006.11.22
申请国别(地区):
NO
年份:
2012
代理人:
摘要:
The present invention relates to highly pure, crystalline, stable compounds of novel derivatives of 3,3-diphenylpropylamines in the form of their salts of the general formula I, and to a process for their preparation by making use of highly pure, stable intermediate products of the general formula 1. The invention also relates to a process for preparing the above-described derivatives wherein the preparation process thereof is characterized in that a compound of the general formula III is split with a hydrogenation agent to form a compound of the general formula V whereupon the compound of the general formula V so obtained is converted with a reducing agent, in order to give a compound of the general formula VI, which is converted with an acylation agent, in order to obtain a compound of the general formula A, which is converted with a physiologically compatible inorganic or organic acid to form a compound of the general formula I wherein the preparation process is particular further characterized by regio- and chemoselectivity and high yield.Anvendelse av R-(+)-2-(3 -diisopropylamino-l-fenylpropyl)-4-hydroksymetyl-fenylisosmørsyre- hydrogenfimiarat eller den krystallinske form av R-(+)-2-(3-diisopropylamino-l-fenylpropyl)-4- hydroksymetyl-fenylisosmørsyrehydrogenfimiaratfor fremstilling av et medikament for behandling av urininkontinens og andre spasmogeniske sykdommer.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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