PROBLEM TO BE SOLVED: To provide a method for improving or preventing various conditions through suppression of the expression of inflammatory cytokines based on the action mechanism of suppression of NF-κB activation.SOLUTION: The present invention provides a composition for suppressing NF-κB activation, containing a serotonin derivative, a composition for suppressing the expression of VCAM-1 and/or MCP-1 via NF-κB, containing the serotonin derivative and an anti-inflammatory composition containing the serotonin derivative. The composition of the present invention can be used as a pharmaceutical agent or a food.COPYRIGHT: (C)2013,JPO&INPIT【課題】NF-κB活性化の抑制を作用機序とする炎症性サイトカインの発現抑制を通じて様々な症状の改善または予防手段を提供する。【解決手段】セロトニン誘導体を含有してなるNF-κB活性化抑制用組成物、セロトニン誘導体を含有してなる、NF-κBを介したVCAM-1および/またはMCP-1の発現抑制用組成物ならびにセロトニン誘導体を含有してなる抗炎症用組成物。本発明の組成物は、医薬または食品として用いられる。【選択図】図1
