EAI assay background - .4 a 1500- C) ea 4 3) 1000- o 500- 40• (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 08 November 2018 (08.11.2018) WI PO I PCT o n ono oIIIDIDIIIIIMD1111010lII1111111 Hs (10) International Publication Number WO 2018/204427 Al (51) International Patent Classification: A61K 35/17 (2015.01) A61P 35/00 (2006.01) A61K 31/454 (2006.01) (21) International Application Number: PCT/US2018/030545 (22) International Filing Date: 01 May 2018 (01.05.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/492,947 01 May 2017 (01.05.2017) US 62/538,670 29 July 2017 (29.07.2017) US 62/549,390 23 August 2017 (23.08.2017) US 62/580,433 01 November 2017 (01.11.2017) US 62/596,753 08 December 2017 (08.12.2017) US (71) Applicant: JUNO THERAPEUTICS, INC. [US/US]； 400 Dexter Ave. N, Suite 1200, Seattle, WA 98109 (US). (72) Inventors: PORTS, Michael； C/o Juno Therapeutics, Inc., 400 Dexter Ave. N, Suite 1200, Seattle, WA 98109 (US). WORKS, Melissa； C/o Juno Therapeutics, Inc., 400 Dexter Ave. N, Suite 1200, Seattle, WA 98109 (US). (74) Agent: POTTER, Karen et al.； Morrison & Foerster LLP, 12531 High Bluff Drive, Suite 100, San Diego, CA 92130-2040 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, (54) Title: COMBINATION OF A CELL THERAPY AND AN IMMUNOMODULATORY COMPOUND FIG. 1A 2500- N O 00 11 O C (57) : The present disclosure relates in some aspects to methods, compositions and uses involving immunotherapies, such as adoptive cell therapy, e.g., T cell therapy,
