An injection system for transferring a volume of fluid from a syringe into a patient comprises a syringe assembly having a syringe adapter configured to securely receive a pre-filled syringe and a plunger assembly configured to be selectively moved relative to the syringe adapter. The injection system further comprises a fluid delivery module comprising at least one motor to move an actuator in at least one direction. In some embodiments, the injection system additionally comprises a motion transfer cable. In one embodiment, one end of the motion transfer cable is mechanically coupled to the actuator of the fluid delivery module, and the other end is mechanically coupled to the plunger assembly of the syringe assembly. In some embodiments, movement of the actuator by the motor is transferred through the motion transfer cable to the plunger assembly, resulting in the plunger assembly moving a desired distance relative to the pre-filled syringe.