PROBLEM TO BE SOLVED: To provide a pharmaceutical composition in which the problem of the stability between a xanthine derivative or the like, and loxoprofen or a salt thereof is improved.SOLUTION: A pharmaceutical composition comprises loxoprofen or a salt thereof and an ephedrine such that they are not in contact with each other substantially.SELECTED DRAWING: NoneCOPYRIGHT: (C)2017,JPO&INPIT【課題】キサンチン誘導体等と、ロキソプロフェン又はその塩との間の安定性の問題が改善された医薬組成物の提供。【解決手段】ロキソプロフェン又はその塩とエフェドリン類とを実質的に互いに接しないように含有する医薬組成物。【選択図】なし