Ira S. Mellman,Tarek M. Fahmy,William Mark Saltzman,Michael J. Caplan
申请号：
US12527143
公开号：
US08889117B2
申请日:
2008.02.15
申请国别(地区):
US
年份:
2014
代理人:
摘要：
Modular nanoparticle vaccine compositions and methods of making and using the same have been developed. Modular nanoparticle vaccine compositions comprise an antigen encapsulated in a polymeric particle and adaptor elements which modularly couple functional elements to the particle. The modular design of these vaccine compositions, which involves flexible addition and subtraction of antigen, adjuvant, immune potentiators, molecular recognition and transport mediation elements, as well as intracellular uptake mediators, allows for exquisite control over variables that are important in optimizing an effective vaccine delivery system.
