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DE NOVO DESIGN OF PROTEIN SWITCHES
专利权人:
UNIVERSITY OF WASHINGTON
发明人:
Robert A. LANGAN,Scott BOYKEN,David BAKER,Walter NOVAK,Marc Joseph LAJOIE,Alfredo QUIJANO RUBIO
申请号:
US16796009
公开号:
US20200239524A1
申请日:
2020.02.20
申请国别(地区):
US
年份:
2020
代理人:
摘要:
Disclosed are protein switches that can sequester bioactive peptides and/or binding domains, holding them in an inactive (“off”) state, until combined with a second designed polypeptide called the key, which induces a conformational change that activates (“on”) the bioactive peptide or binding domain, components of such protein switches, and their use.
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