Грин, Мартин Ричард,Джинджер, Ребекка Сьюзан,Глен, Роберт Чарльз
申请号：
EA201690591
公开号：
EA201690591A1
申请日:
2014.10.14
申请国别(地区):
EA
年份:
2016
代理人:
摘要：
the desired color is one of the main pressing needs of consumers all over the world and particularly in asia. consumers, in particular, the need to smooth the skin color, the lack of age spots (solar \u043b\u0435\u043d\u0442\u0438\u0433\u043e), lack of \u0433\u0438\u043f\u0435\u0440\u043f\u0438\u0433\u043c\u0435\u043d\u0442\u0430\u0446\u0438\u0438 and more bright, the tone of the skin.one of the solutions is the application of biologically active substances that inhibit the activity of the cells \u043c\u0435\u043b\u0430\u043d\u043e\u0446\u0438\u0442\u043e\u0432 in skin. these cells are present in the \u0431\u0430\u0437\u0430\u043b\u044c\u043d\u043e\u043c layer of epidermis, produce a dark colored pigment melanin and is transported in the small transport \u0432\u0435\u0437\u0438\u043a\u0443\u043b\u0430\u0445, as \u043c\u0435\u043b\u0430\u043d\u043e\u0441\u043e\u043c\u0430\u043c\u0438 in neighbouring \u043a\u0435\u0440\u0430\u0442\u0438\u043d\u043e\u0446\u0438\u0442\u044b.from the literature it is well known that compounds which inhibit the synthesis of melanin in the local coating on the skin, diminish over time and may on dark skin tone \u0435\u0441\u043f\u0435\u0447\u0438\u0432\u0430\u0442\u044c evens skin tones. tyrosinase is a widely used target for the regulation of pigment \u043c\u0435\u043b\u0430\u043d\u043e\u0446\u0438\u0442\u043e\u0432.however, effective inhibitors \u0442\u0438\u0440\u043e\u0437\u0438\u043d\u0430\u0437\u044b may be insecure, causing, for example, the loss of \u043c\u0435\u043b\u0430\u043d\u043e\u0446\u0438\u0442\u043e\u0432, constant \u0434\u0435\u043f\u0438\u0433\u043c\u0435\u043d\u0442\u0430\u0446\u0438\u044e, irritation and allergic re the stock. often effective inhibitors destroy melanocyte (e.g. hydroquinone) or generate a response sensitization.consequently, there is a great need for safe and effective \u0438\u043d\u0433\u0438\u0431\u0438\u0442\u043e\u0440\u0430\u0445 of skin pigment, which operate through alternative the safe mechanis
