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Glycodendrimers of polypropyletherimine
专利权人:
Sunil Shaunak
发明人:
Sunil Shaunak,Ian Alfred Teo
申请号:
US13818580
公开号:
US09453040B2
申请日:
2011.08.22
申请国别(地区):
US
年份:
2016
代理人:
摘要:
A glycodendrimer comprising: a) a non-toxic dendrimer polypropyletherimine core supporting on average in the range of 9 to 64 terminal carboxylic acid groups, and b) conjugated to said core in the range of 2 to 8 amino sugars or a sulphate amino sugar selected from the group consisting of glucosamine, N-acetyl glucosamine, mannosamine, N-acetylmannosamine, galactosamine, a sulphate of any one of the same and a combination thereof, wherein each sugar is linked directly through a zero length amide bond with a residue of a terminal carboxylic acid group. The invention also extends to defined populations comprising said glycodendrimer molecules, pharmaceutical compositions comprising said molecules or populations, process for preparing the molecules and formulations, and therapeutic uses of the molecules, populations and compositions.
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