Provided in the present invention is a composition to prevent and treat cancer which comprises attenuated salmonella species strain and interleukin-1&beta (IL-1&beta) to increase an anticancer effect of attenuated anaerobic bacteria for treatment. According to an embodiment of the present invention formed like the same, a composition to prevent and treat cancer, and a treatment method using the same increasing the anticancer effect of the attenuated salmonella strain can be provided.COPYRIGHT KIPO 2014본 발명은 치료용 약독화 혐기성 박테리아의 항암 효과를 증가시키기 위해, 약독화된 살모넬라 속 균주 및 IL-1β(interleukin-1β)를 포함하는, 암 예방 및 치료용 조성물을 제공한다.