An autoinjector has a body (10, 12), a syringe (13) or cartridge having a needle at its forward end disposed in the body, a drive mechanism (60 . . . ) for being released on activation of a trigger element (18) to operate the autoinjector, the trigger element being mounted in a recess or opening in the body for movement relative to the body from a rest position to a fire position, wherein one of the trigger element and the adjacent surface of the body portion is provided with a contact surface (34) which is resiliently urgeable into sliding contact with a cooperating surface (36) on the other, to provide resistance to movement of the trigger towards the firing position.