Ellen S. Vitetta,Victor F. Ghetie,Joan E. Smallshaw,Roxana G. Baluna
申请号：
US11673981
公开号：
US08323665B2
申请日:
2007.02.12
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The present invention provides methods to produce toxoid vaccines, such as ricin A chain vaccines, with reduced ability to promote vascular leak syndrome (VLS) and catalytic toxicity associated with various proteinaceous toxins, such as ribosome inactivating proteins. The invention also provides toxoids which have been mutated to lack amino acid sequences which induce VLS and toxic catalytic activity.
