ÉRADICATION DE L'HERPÈS SIMPLEX DE TYPE I ET D'AUTRES VIRUS DE L'HERPÈS ASSOCIÉS GUIDÉE PAR ARN

• 收藏
• 分享

专利权人:

Temple University Of The Commonwealth System Of Higher Education

发明人:

ROEHM, Pamela, C.,KHALILI, Kamel,SHEKARABI, Sayed, Masoud,WOLLEBO, Hassen

申请号：

EP16737885

公开号：

EP3244932A4

申请日:

2016.01.14

申请国别(地区):

EP

年份:

2018

代理人:

摘要：

The present invention relates to compositions and methods for the inhibition of the infectivity of a herpesvirus. In certain embodiments, the compositions and methods provide a CRISPR-associated peptide and a guide nucleic acid, which induce the mutation of herpesvirus genome, thereby inhibiting the infectivity of the herpesvirus. Further disclosed are Cas peptides including Cas9 or a variant thereof comprising one or more point mutations relative to wildtype Streptococcus pyogenes Cas 9 (spCas9), and Cpf1 or a variant thereof.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/