Robert G. Schmidt, Jr.;Guo Zhu Zheng;Richard J. Perner;Stanley Didomenico, Jr.;John R. Koenig;Irene Drizin;Tammie K. White;Erol K. Bayburt;Chih-Hung Lee;Arthur R. Gomtsyan;Sean C. Turner
发明人:
Chih-Hung Lee,Erol K. Bayburt,Stanley Didomenico, Jr.,Irene Drizin,Arthur R. Gomtsyan,John R. Koenig,Richard J. Perner,Robert G. Schmidt, Jr.,Sean C. Turner,Tammie K. White,Guo Zhu Zheng
申请号：
US12033233
公开号：
US08247413B2
申请日:
2008.02.19
申请国别(地区):
US
年份:
2012
代理人:
摘要：
Compounds of formula (I)are novel VR1 antagonists that are useful in treating pain, inflammatory thermal hyperalgesia, urinary incontinence and bladder overactivity, wherein X1, X2, X3, X4, X5, R5, R6, R7, R8a, R8b, R9, Z1, Z2 and L are as defined in the description.
