RICHARD, HOOGENBOOM,JOHANNES CASPAR MATHIAS ELIZABETH, BENDER,JAN CORNELIS MARIA VAN, HEST
申请号：
TR201909167
公开号：
TR201909167T4
申请日:
2012.01.02
申请国别(地区):
TR
年份:
2019
代理人:
摘要：
One aspect of the invention relates to a biocompatible, covalently cross-linked, polymer that is obtained by reacting an electrophilically activated polyoxazoline (EL-POX) with a nucleophilic cross-linking agent, said electrophilically activated POX comprising m electrophilic groups； and said nucleophilic cross-linking agent comprising n nucleophilic groups, wherein the m electrophilic groups are capable of reaction with the n nucleophilic groups to form covalent bonds； wherein m≥2, n≥2 and m+n ≥5； wherein at least one of the m electrophilic groups is a pendant electrophilic group and/or wherein m≥3； and wherein the EL-POX comprises an excess amount of electrophilic groups relative to the amount of nucleophilic groups contained in the nucleophilic cross-linking agent. The invention further relates to biocompatible medical products comprising such a cross-linked POX-polymer. Also provided is a kit for producing a biocompatible, cross-linked POX-polymer. The invention further provides a tissue adhesive medical product comprising at least 1% by weight of dry matter of EL-POX, said EL-POX comprising at least 2 electrophilic groups, including at least one pendant electrophilic group. The polymers according to the invention have excellent implant and/or sealing characteristics.Buluşun bir açısı, elektrofilik olarak aktive edilmiş polioksazolinin (EL-POX) nükleofilik çapraz bağlayıcı ajan ile reakte edilmesi yoluyla elde edilen biyouyumlu, kovalent olarak çapraz bağlı bir polimer ile ilgilidir, söz konusu elektrofilik olarak aktive edilmiş POX, m sayıda elektrofilik grup içerir； ve söz konusu nükleofilik çapraz bağlayıcı ajan, n sayıda nükleofilik grup içerir, burada m sayıdaki elektrofilik gruplar, kovalent bağları oluşturmak üzere n sayıdaki nükleofilik gruplar ile reakte olabilir； burada =2, n=2 ve m+n =5'tir； m sayıdaki elektrofilik gruplardan en az biri, asılı elektrofilik gruptur ve/veya m=3'tür； ve EL-POX, nükleofilik çapraz bağlayıcı ajanda bulunan nükleofilik grup
