Richard HOOGENBOOM,Johannes Caspar Mathias Elizabeth BENDER,Jan Cornelis Maria VAN HEST
申请号:
US16378245
公开号:
US20190231923A1
申请日:
2019.04.08
申请国别(地区):
US
年份:
2019
代理人:
摘要:
A biocompatible, covalently cross-linked, polymer that is obtained by reacting an electrophilically activated polyoxazoline (EL-POX) with a nucleophilic cross-linking agent is disclosed. The EL-POX comprises m electrophilic groups; and the nucleophilic cross-linking agent comprises n nucleophilic groups, wherein the m electrophilic groups are capable of reacting with the n nucleophilic groups to form covalent bonds; wherein m≥;2, n≥;2 and m+n≥;5; wherein at least one of the m electrophilic groups is a pendant electrophilic group and/or wherein m≥;3; and wherein to the EL-POX comprises an excess amount of electrophilic groups relative to the amount of nucleophilic groups contained in the nucleophilic cross-linking agent. Biocompatible medical products and kits comprising the cross-linked POX-polymers are also disclosed.