Richard HOOGENBOOM,Johannes Caspar Mathias Elizabeth BENDER,Jan Cornelis Maria VAN HEST
申请号：
US16378245
公开号：
US20190231923A1
申请日:
2019.04.08
申请国别(地区):
US
年份:
2019
代理人:
摘要：
A biocompatible, covalently cross-linked, polymer that is obtained by reacting an electrophilically activated polyoxazoline (EL-POX) with a nucleophilic cross-linking agent is disclosed. The EL-POX comprises m electrophilic groups； and the nucleophilic cross-linking agent comprises n nucleophilic groups, wherein the m electrophilic groups are capable of reacting with the n nucleophilic groups to form covalent bonds； wherein m≥；2, n≥；2 and m+n≥；5； wherein at least one of the m electrophilic groups is a pendant electrophilic group and/or wherein m≥；3； and wherein to the EL-POX comprises an excess amount of electrophilic groups relative to the amount of nucleophilic groups contained in the nucleophilic cross-linking agent. Biocompatible medical products and kits comprising the cross-linked POX-polymers are also disclosed.
