ZHANG JIAZHONG,IBRAHIM PRABHA N,BREMER RYAN,SPEVAK WAYNE,CHO HANNA
申请号：
IN3959/CHENP/2012
公开号：
IN2012CN03959A
申请日:
2012.05.03
申请国别(地区):
IN
年份:
2016
代理人:
摘要：
Abstract: COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR Compounds and salts thereof, formulations thereof, conjugates thereof, derivatives thereof, forms thereof and uses thereof are described. In certain aspects and embodiments, the described compounds or salts thereof, formulations thereof, coujugates thereof, derivatives thereof, or forms thereof are active on Fms protein kinase, or on Fms and Kit protein kinase, or on Fms and Flt-3 protein kinase. Also described are methods of use thereof to treat diseases and conditions, including diseases and conditions associated with activity of Fms protein kinase, Kit protein kinase, or Flt-3 protein kinase including rheumatoid arthiritis, osteoarthritis, multiple sclerosis, Atzheimer"s disease, Parkinson"s disease, glomerulonephritis, interstitial nephritis, Lupris nephritis, tubular necrosis, diabetic nephropathy, renal hypertrophy, acute myeloid leukemia, melanoma, multiple myeloma, metastatic breast cancer, prostate cancer, pancreatic cancer, neurofibromatosis, brain metastases, and gastrointestinal stromal tumors.
